VU 0409551

Tocris Bioscience, part of Bio-Techne | Catalog # 5693

Selective positive allosteric modulator of mGlu5 receptors; brain penetrant and orally bioavailable
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Key Product Details

Description

Selective positive allosteric modulator of mGlu5 receptors; brain penetrant and orally bioavailable

Alternative Names

JNJ 46778212

View all Group I mGluR Modulators »

Product Description

VU 0409551 is a selective mGlu5 positive allosteric modulator (EC50 = 260 nM). Selective for mGlu5 over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5 signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models. Brain penetrant and orally available.

Product Specifications

Molecular Weight

352.36

Formula

C20H17FN2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone

CAS Number

1363281-27-9

PubChem ID

56846694

InChI Key

QUZLMKNNIUSREV-UHFFFAOYSA-N

SMILES

O=C(C1=CC=C(F)C=C1)N(C2)CCC3=C2OC(COC4=CC=CC=C4)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.24 100
Ethanol 17.62 50

Preparing Stock Solutions for VU 0409551

The following data is based on the product molecular weight 352.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Documents for VU 0409551

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 0409551

For research use only

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