VU 0255035
Tocris Bioscience, part of Bio-Techne | Catalog # 3727
Highly selective M1 antagonist
Product Description
VU 0255035 is a highly selective muscarinic M1 antagonist (Ki = 14.87 nM). Targets the M1 orthosteric site with greater than 75-fold selectivity over the other receptor subtypes. Reduces pilocarpine-induced seizures in mice. Brain penetrant.Product Specifications
Molecular Weight
432.52
Formula
C18H20N6O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide
CAS Number
1135243-19-4
PubChem ID
24768606
InChI Key
WXDHQWPQLKGANZ-UHFFFAOYSA-N
SMILES
O=C(CCNS(C4=CC=CC3=NSN=C34)(=O)=O)N(CC2)CCN2C1=CC=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.65 | 20 |
Preparing Stock Solutions
for VU 0255035
The following data is based on the product molecular weight 432.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.56 mL | 57.80 mL | 115.60 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 2 mM | 1.16 mL | 5.78 mL | 11.56 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sheffler A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol.Pharmacol. 2009 PMID: 19407080
Product Specific Notices for VU 0255035
For research use only
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