VT 104

Name: VT 104
Brand: Tocris Bioscience
SKU: 8176

Tocris Bioscience, part of Bio-Techne | Catalog # 8176

COA / SDS

Potent pan-TEAD inhibitor

Key Product Details

Description:	Potent pan-TEAD inhibitor
Chemical Name:	N-[(1S)-1-(2-Pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	420.43

View Full Technical Details for VT 104

Technical Data
Citations

Biological Activity for VT 104

VT 104 is a potent pan-TEAD (transcriptional enhanced associate domain) inhibitor (IC₅₀ = 10.4 nM). VT 104 inhibits YAP/TAZ-TEAD promoted gene transcription by preventing the association between YAP/TAZ and TEAD. VT 104 blocks TEAD auto-palmitoylation. In vitro, VT 104 inhibits NF2-deficient mesothelioma cell proliferation, and growth of subcutaneous tumor xenografts in vivo. VT 104 is orally bioavailable.

Technical Data for VT 104

M. Wt	420.43
Formula	C₂₅H₁₉F₃N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2417718-25-1
PubChem ID	146909371
InChi Key	AAZUPSFRSHFTGV-INIZCTEOSA-N
Smiles	C(N[C@@H](C)C1=CC=CC=N1)(=O)C2=CC3=C(C(=CC=C3)C4=CC=C(C(F)(F)F)C=C4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VT 104

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.04	100
	ethanol	21.02	50

Preparing Stock Solutions for VT 104

The following data is based on the product molecular weight 420.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.79 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for VT 104

References are publications that support the biological activity of the product.

Tang Small molecule inhibitors of TEAD auto-palmitoylation selectively inhibit proliferation and tumor growth of NF2-deficient mesothelioma. Mol.Cancer Ther. 2021 PMID: 33850002