VPC 23019
Tocris Bioscience, part of Bio-Techne | Catalog # 4195
S1P1 and S1P3 antagonist
Key Product Details
Description
S1P1 and S1P3 antagonist
Product Description
VPC 23019 is a sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).Product Specifications
Molecular Weight
372.40
Formula
C17H29N2O5P
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide
CAS Number
449173-19-7
PubChem ID
11588811
InChI Key
MRUSUGVVWGNKFE-MRXNPFEDSA-N
SMILES
O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Acidified DMSO (5% 1N HCl in DMSO) | 3.72 | 10 with gentle warming | |
| 2eq. NaOH | 18.62 | 50 |
Preparing Stock Solutions
for VPC 23019
The following data is based on the product molecular weight 372.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.37 mL | 26.85 mL | 53.71 mL |
| 2.5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 25 mM | 0.11 mL | 0.54 mL | 1.07 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aoki The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 2007 PMID: 17403093
- Mihovilovic High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 2007 PMID: 17264352
- Davis Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 2005 PMID: 15590668
Product Specific Notices for VPC 23019
For research use only
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