Vismodegib
Tocris Bioscience, part of Bio-Techne | Catalog # 7710
Potent hedgehog pathway inhibitor
Key Product Details
Description
Potent hedgehog pathway inhibitor
Product Description
Vismodegib is a potent hedgehog pathway inhibitor (IC50 = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.Product Specifications
Molecular Weight
421.30
Formula
C19H14Cl2N2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
CAS Number
879085-55-9
PubChem ID
24776445
InChI Key
BPQMGSKTAYIVFO-UHFFFAOYSA-N
SMILES
O=C(NC=1C=CC(Cl)=C(C1)C2=NC=CC=C2)C3=CC=C(C=C3Cl)S(=O)(=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.13 | 100 |
Preparing Stock Solutions
for Vismodegib
The following data is based on the product molecular weight 421.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.87 mL | 23.74 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.75 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wong Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 2009 PMID: 19845436
- Wong Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin.Cancer Res. 2011 PMID: 21610148
- Robarge GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg.Med.Chem.Lett. 2009 PMID: 19716296
Product Specific Notices for Vismodegib
For research use only
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