Vinblastine sulfate

Name: Vinblastine sulfate
Brand: Tocris Bioscience
SKU: 1256
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1256

(1)

Citations (8)

COA / SDS

Disrupts microtubules

Key Product Details

Description:	Disrupts microtubules
Chemical Name:	Vincaleukoblastine
Purity:	≥95% (HPLC)
Molecular Weight:	909.06

View Full Technical Details for Vinblastine sulfate

Technical Data
Citations / Reviews (1)

Biological Activity for Vinblastine sulfate

Vinblastine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Technical Data for Vinblastine sulfate

M. Wt	909.06
Formula	C₄₆H₅₈N₄O₉.H₂SO₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	143-67-9
PubChem ID	241902
InChi Key	KDQAABAKXDWYSZ-JKDPCDLQSA-N
Smiles	OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vinblastine sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	90.91	100
	DMSO	90.91	100

Preparing Stock Solutions for Vinblastine sulfate

The following data is based on the product molecular weight 909.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.10 mL	5.50 mL	11.00 mL
5 mM	0.22 mL	1.10 mL	2.20 mL
10 mM	0.11 mL	0.55 mL	1.10 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

Molarity Calculator

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Reconstitution Calculator

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References for Vinblastine sulfate

References are publications that support the biological activity of the product.

Veldhoen The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 2012 PMID: 22430212
Rai and Wolf Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 1998 PMID: 9813016
Tsukidate Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 1993 PMID: 8362985
Jordan Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 PMID: 3986806

Product Documents for Vinblastine sulfate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Vinblastine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov