Vinblastine sulfate

Name: Vinblastine sulfate
Brand: Tocris Bioscience
SKU: 1256
Rating: 5 (1 reviews)

Catalog # 1256 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (6)

COA / SDS

Disrupts microtubules

Key Product Details

Description:	Disrupts microtubules
Chemical Name:	Vincaleukoblastine
Purity:	≥95% (HPLC)
Molecular Weight:	909.06

View Full Technical Details for Vinblastine sulfate

Technical Data
Citations (6) / Reviews (1)

Biological Activity for Vinblastine sulfate

Vinblastine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Technical Data for Vinblastine sulfate

M. Wt	909.06
Formula	C₄₆H₅₈N₄O₉.H₂SO₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	143-67-9
PubChem ID	241902
InChi Key	KDQAABAKXDWYSZ-JKDPCDLQSA-N
Smiles	OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vinblastine sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	90.91	100
	DMSO	90.91	100

Preparing Stock Solutions for Vinblastine sulfate

The following data is based on the product molecular weight 909.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.10 mL	5.50 mL	11.00 mL
5 mM	0.22 mL	1.10 mL	2.20 mL
10 mM	0.11 mL	0.55 mL	1.10 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

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Reconstitution Calculator

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References for Vinblastine sulfate

References are publications that support the biological activity of the product.

Veldhoen The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 2012 PMID: 22430212
Rai and Wolf Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 1998 PMID: 9813016
Tsukidate Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 1993 PMID: 8362985
Jordan Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 PMID: 3986806

Citations for Vinblastine sulfate (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Vinblastine sulfate include:

Bernier et al. (2019) Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia. Cell Rep. 27:2895
PMID: 31167136
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther. 16(6):1021
PMID: 28265007
Kathawala et al. (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget. 6:510
PMID: 25402202
Kathawala et al. (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther. 13:714
PMID: 24431074
Musiwaro et al. (2013) Characteristics and requirements of basal autophagy in HEK 293 cells. BMC Cancer. 9:1407
PMID: 23800949
Ahmad et al. (2010) Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells. Trop Life Sci Res. 21:101
PMID: 24575203

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Customer Reviews for Vinblastine sulfate (1)

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007

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