Vinblastine sulfate
Tocris Bioscience, part of Bio-Techne | Catalog # 1256
Disrupts microtubules
Product Description
Vinblastine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.Product Specifications
Molecular Weight
909.06
Formula
C46H58N4O9.H2SO4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
Vincaleukoblastine
CAS Number
143-67-9
PubChem ID
241902
InChI Key
KDQAABAKXDWYSZ-JKDPCDLQSA-N
SMILES
OS(O)(=O)=O.[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 90.91 | 100 | |
| DMSO | 90.91 | 100 |
Preparing Stock Solutions
for Vinblastine sulfate
The following data is based on the product molecular weight 909.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.10 mL | 5.50 mL | 11.00 mL |
| 5 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.10 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Veldhoen The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 2012 PMID: 22430212
- Rai and Wolf Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 1998 PMID: 9813016
- Tsukidate Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 1993 PMID: 8362985
- Jordan Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 PMID: 3986806
Product Specific Notices for Vinblastine sulfate
For research use only
⚠ WARNING: This product can expose you to chemicals including Vinblastine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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