Vigabatrin
Tocris Bioscience, part of Bio-Techne | Catalog # 0808
GABA-T inhibitor
Key Product Details
Description
GABA-T inhibitor
Alternative Names
(±)-γ-Vinyl GABA
Product Description
Vigabatrin is a selective GABA-T (transaminase) inhibitor. Anticonvulsant.Product Specifications
Molecular Weight
129.16
Formula
C6H11NO2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Aminohexenoic acid
CAS Number
68506-86-5
PubChem ID
5665
InChI Key
PJDFLNIOAUIZSL-UHFFFAOYSA-N
SMILES
NC(C=C)CCC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 12.92 | 100 |
Preparing Stock Solutions
for Vigabatrin
The following data is based on the product molecular weight 129.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.74 mL | 38.71 mL | 77.42 mL |
| 5 mM | 1.55 mL | 7.74 mL | 15.48 mL |
| 10 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 50 mM | 0.15 mL | 0.77 mL | 1.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Larsson Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 1986 PMID: 3092125
- Schmid Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 1996 PMID: 8786578
- Halonen Effects of vigab. (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 1991 PMID: 1672276
Product Specific Notices for Vigabatrin
For research use only
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