VHF 543, amine
Tocris Bioscience, part of Bio-Techne | Catalog # 8075
DCAF1 WD40 ligand with terminal amine for onward chemistry
Key Product Details
Description
DCAF1 WD40 ligand with terminal amine for onward chemistry
Product Description
VHF 543, amine is a potent ligand for the WD40 repeat domain (WDR) of DCAF1 (Kd = 31 nM measured by surface plasmon resonance). VHF 543, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
507.08
Formula
C28H35ClN6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(4-(4-((2-Aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)ethan-1-one
CAS Number
3053860-67-3
PubChem ID
168069227
InChI Key
GGEKTDCCHNVLNE-UHFFFAOYSA-N
SMILES
NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=CC(N5CCN(CC5)C(C)=O)=CC=C41
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.14 | 20 |
Preparing Stock Solutions
for VHF 543, amine
The following data is based on the product molecular weight 507.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.86 mL | 49.30 mL | 98.60 mL |
| 1 mM | 1.97 mL | 9.86 mL | 19.72 mL |
| 2 mM | 0.99 mL | 4.93 mL | 9.86 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vulpetti Discovery of new binders for DCAF1, an emerging ligase target in the targeted protein degradation field. ACS Med.Chem.Lett. 2023 PMID: 37465299
Product Specific Notices for VHF 543, amine
For research use only
Loading...
Loading...