VHF 543, amine

Name: VHF 543, amine
Brand: Tocris Bioscience
SKU: 8075

Tocris Bioscience, part of Bio-Techne | Catalog # 8075

COA / SDS

DCAF1 WD40 ligand with terminal amine for onward chemistry

Key Product Details

Description:	DCAF1 WD40 ligand with terminal amine for onward chemistry
Chemical Name:	1-(4-(4-((2-Aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)ethan-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	507.08

View Full Technical Details for VHF 543, amine

Technical Data
Citations

Biological Activity for VHF 543, amine

VHF 543, amine is a potent ligand for the WD40 repeat domain (WDR) of DCAF1 (K_d = 31 nM measured by surface plasmon resonance). VHF 543, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for VHF 543, amine

M. Wt	507.08
Formula	C₂₈H₃₅ClN₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3053860-67-3
PubChem ID	168069227
InChi Key	GGEKTDCCHNVLNE-UHFFFAOYSA-N
Smiles	NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=CC(N5CCN(CC5)C(C)=O)=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VHF 543, amine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.14	20

Preparing Stock Solutions for VHF 543, amine

The following data is based on the product molecular weight 507.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.86 mL	49.30 mL	98.60 mL
1 mM	1.97 mL	9.86 mL	19.72 mL
2 mM	0.99 mL	4.93 mL	9.86 mL
10 mM	0.20 mL	0.99 mL	1.97 mL

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Reconstitution Calculator

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References for VHF 543, amine

References are publications that support the biological activity of the product.

Vulpetti Discovery of new binders for DCAF1, an emerging ligase target in the targeted protein degradation field. ACS Med.Chem.Lett. 2023 PMID: 37465299