VH 101, thiol

Name: VH 101, thiol
Brand: Tocris Bioscience
SKU: 7884

Tocris Bioscience, part of Bio-Techne | Catalog # 7884

COA / SDS

Thiol functionalized VHL ligand

Key Product Details

Description:	Thiol functionalized VHL ligand
Chemical Name:	(2S,4R)-1-[(2R)-2-[[(1-Fluorocyclopropyl)carbonyl]amino]-3-methyl-3-sulfanyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	534.67

View Full Technical Details for VH 101, thiol

Technical Data
Citations

Biological Activity for VH 101, thiol

VH 101, thiol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand with terminal thiol ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 101, thiol

M. Wt	534.67
Formula	C₂₅H₃₁FN₄O₄S₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2358775-81-0
InChi Key	RCVHBJGYHDKFGZ-WSTZPKSXSA-N
Smiles	O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 101, thiol

References are publications that support the biological activity of the product.

Liu Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood-brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2. J.Am.Chem.Soc. 2022 PMID: 36007011