VH 101, phenol

Name: VH 101, phenol
Brand: Tocris Bioscience
SKU: 6952

Tocris Bioscience, part of Bio-Techne | Catalog # 6952

Citations (1)

COA / SDS

Hydroxyl functionalized VHL ligand

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Technical Data
Citations

Product Description
Licensing Information
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Hydroxyl functionalized VHL ligand

View all Functionalized E3 Ligand Building Blocks »

Product Description

VH 101, phenol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under licence from the University of Dundee.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

532.63

Formula

C₂₆H₃₃FN₄O₅S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2306193-99-5

PubChem ID

137628614

InChI Key

OKBLHQUBMCCFKE-LVCYWYKZSA-N

SMILES

CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C4(CC4)F)=O)C(C)(C)C)=O)=O)C(O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Maniaci Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Commun. 2017 PMID: 29018234
Girardini Cereblon versus VHL: hijacking E3 ligases against each other using PROTACs. Bioorg.Med.Chem. 2019 PMID: 30826187
Farnaby BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat.Chem.Biol. 2019 PMID: 31178587
Zoppi Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast, and selective Von Hippel-Lindau (VHL) based dual degrader probe of BRD9 and BRD7. J.Med.Chem. 2019 PMID: 30540463