VH 032, propargyl
Tocris Bioscience, part of Bio-Techne | Catalog # 6683
Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs
Key Product Details
Description
Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs
Product Description
VH 032, propargyl is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal propargyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
526.65
Formula
C27H34N4O5S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2098799-78-9
SMILES
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCC#C)=O)=O)O)=O)SC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wurz A "click chemistry platform" for the rapid synthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 2018 PMID: 28378579
Product Specific Notices for VH 032, propargyl
For research use only
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