VH 032 amide-PEG3-BCN
Tocris Bioscience, part of Bio-Techne | Catalog # 8123
Functionalized VHL building block for copper-free click chemistry
Key Product Details
Description
Functionalized VHL building block for copper-free click chemistry
Product Description
VH 032 amide-PEG3-BCN is a functionalized von Hippel Lindau (VHL) protein ligand for PROTAC® research and development. Incorporates an E3 ligase ligand plus a PEG3 linker with terminal bicyclooctyne (BCN). It can be used for copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. Part of a range of functionalized tool molecules for PROTAC R&D.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
810.02
Formula
C42H59N5O9S
Storage
Store at -20°C
Purity
≥90% (HPLC)
Chemical Name
((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
CAS Number
2876198-36-4
PubChem ID
169450546
InChI Key
WLQVZOBNMRIBKF-LLQRHEORSA-N
SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC(OC[C@H]4[C@]5([H])[C@@]4([H])CCC#CCC5)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu TF-PROTACs enable targeted degradation of transcription factors. J.Am.Chem.Soc. 2021 PMID: 34100597
Product Specific Notices for VH 032 amide-PEG3-BCN
For research use only
Loading...
Loading...