VH 032 amide-PEG2-alkyne

Name: VH 032 amide-PEG2-alkyne
Brand: Tocris Bioscience
SKU: 6684

Tocris Bioscience, part of Bio-Techne | Catalog # 6684

COA / SDS

VHL ligand with PEG linker and terminal alkyne for onward chemistry

Discontinued Product

6684 has been discontinued. View all Degrader Building Blocks products.

Key Product Details

Description:	VHL ligand with PEG linker and terminal alkyne for onward chemistry
Alternative Names:	(S,R,S)-AHPC-PEG2-Alkyne
Chemical Name:	(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	614.75

View Full Technical Details for VH 032 amide-PEG2-alkyne

Technical Data
Citations

Biological Activity for VH 032 amide-PEG2-alkyne

VH 032 amide-PEG2-alkyne is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand plus PEG2 linker with terminal alkyne ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 6

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 amide-PEG2-alkyne

M. Wt	614.75
Formula	C₃₁H₄₂N₄O₇S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2098799-80-3
PubChem ID	132045744
InChi Key	HHXQNDSXTCIWSG-CERRFVOPSA-N
Smiles	CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCCOCCOCC#C)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032 amide-PEG2-alkyne

References are publications that support the biological activity of the product.

Salami Waste disposal-An attractive strategy for cancer therapy. Science 2017 PMID: 28302825
Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 2015 PMID: 26035625