Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC₅₀ = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Product Specifications

Molecular Weight

718.79

Formula

C₄₁H₄₂N₄O₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

CAS Number

129497-78-5

PubChem ID

5362420

InChI Key

YHNBVDZVUQFVLS-SKJZPIBWSA-N

SMILES

CC(C(/C=C1N/C([C@@]2(C)C\1=CC=C(C(OC)=O)[C@H]2C(OC)=O)=C\C3=N/C(C(CCC(O)=O)=C3C)=C\4)=N/5)=C(C=C)C5=C\C6=C(C)C(CCC(OC)=O)=C4N6.CC(C(/C=C7N/C([C@@]8(C)C\7=CC=C(C(OC)=O)[C@H]8C(OC)=O)=C\C9=N/C(C(CCC(OC)=O)=C9C)=C\%10)=N/%11)=C(C=C)C%11=C\C%12=C(C)C(CCC(O)=O)=C%10N%12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	14.38	20

Preparing Stock Solutions for Verteporfin

The following data is based on the product molecular weight 718.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.96 mL	34.78 mL	69.56 mL
1 mM	1.39 mL	6.96 mL	13.91 mL
2 mM	0.70 mL	3.48 mL	6.96 mL
10 mM	0.14 mL	0.70 mL	1.39 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Brodowska The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 2014 PMID: 24837142
Song Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 PMID: 24906622
Liu-Chittenden Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012 PMID: 22677547

Verteporfin

Tocris Bioscience, part of Bio-Techne | Catalog # 5305

Key Product Details

Description

Alternative Names

View all YAP/TAZ Signaling Inhibitors »

Product Description