VER 155008

Name: VER 155008
Brand: Tocris Bioscience
SKU: 3803
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3803

(2)

Citations (52)

COA / SDS

Hsp70 inhibitor

Key Product Details

Description:	Hsp70 inhibitor
Chemical Name:	5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Purity:	≥98% (HPLC)
Molecular Weight:	556.4

View Full Technical Details for VER 155008

Technical Data
Citations / Reviews (2)

Biological Activity for VER 155008

VER 155008 is a novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC₅₀ = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78; displays selectivity against Hsp90β (IC₅₀ >200 μM for Hsp90β).

Compound Libraries for VER 155008

VER 155008 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VER 155008

M. Wt	556.4
Formula	C₂₅H₂₃Cl₂N₇O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1134156-31-2
PubChem ID	25195348
InChi Key	ZXGGCBQORXDVTE-UMCMBGNQSA-N
Smiles	NC1=NC=NC2=C1N=C(NCC5=CC=C(Cl)C(Cl)=C5)N2[C@@H]3O[C@H](COCC4=CC=C(C#N)C=C4)[C@@H](O)[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VER 155008

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.64	100

Preparing Stock Solutions for VER 155008

The following data is based on the product molecular weight 556.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.80 mL	8.99 mL	17.97 mL
5 mM	0.36 mL	1.80 mL	3.59 mL
10 mM	0.18 mL	0.90 mL	1.80 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for VER 155008

References are publications that support the biological activity of the product.

Macias Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J.Med.Chem. 2011 PMID: 21526763
Williamson Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J.Med.Chem. 2009 PMID: 19256508
Massey ATPases as drug targets: insights from heat shock proteins 70 and 90. J.Med.Chem. 2010 PMID: 20608738
Massey A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother.Pharmacol. 2009 PMID: 20012863