VCP 171

Name: VCP 171
Brand: Tocris Bioscience
SKU: 6261

Tocris Bioscience, part of Bio-Techne | Catalog # 6261

Citations (1)

COA / SDS

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

Key Product Details

Description:	Positive allosteric modulator (PAM) of A₁ receptors; also allosteric partial agonist in absence of orthosteric agonist
Chemical Name:	[2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
Purity:	≥98% (HPLC)
Molecular Weight:	347.35

View Full Technical Details for VCP 171

Technical Data
Citations

Biological Activity for VCP 171

VCP 171 is an adenosine A₁ receptor positive allosteric modulator (PAM) (pK_B = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.

Compound Libraries for VCP 171

VCP 171 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VCP 171

M. Wt	347.35
Formula	C₁₈H₁₂F₃NOS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1018830-99-3
PubChem ID	24873485
InChi Key	HNHLVOBHWXLIGP-UHFFFAOYSA-N
Smiles	O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC=C2)C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VCP 171

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.73	100
	ethanol	34.73	100

Preparing Stock Solutions for VCP 171

The following data is based on the product molecular weight 347.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.79 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for VCP 171

References are publications that support the biological activity of the product.

Imlach A positive allosteric modulator of the adenosine A₁ receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model. Mol.Pharmacol. 2015 PMID: 26104547
Aurelio 5-Substituted 2-aminothiophenes as A₁ adenosine receptor allosteric enhancers. Bioorg.Med.Chem. 2008 PMID: 17980606
Christopoulos Role of the second extracellular loop of the adenosine A₁ receptor on allosteric modulator binding, signaling, and cooperativity. Mol.Pharmacol. 2016 PMID: 27683013