VAS 2870

Product Description

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC₅₀ = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.

Solubility

Preparing Stock Solutions for VAS 2870

The following data is based on the product molecular weight 360.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lu VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC Sci.Rep. 2019 PMID: 31827142
• Sancho and Fabregat The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem.Pharmacol. 2011 PMID: 21276422
• ten Freyhaus Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc.Res. 2006 PMID: 16545786
• Stielow Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem.Biophys.Res.Commun. 2006 PMID: 16603125