V 9302 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 8057
ASCT2 (SLC1A5) inhibitor
Key Product Details
Description
ASCT2 (SLC1A5) inhibitor
Product Description
V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC50 = 9.6 μM in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo. V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).Licensing Information
Sold under license from Vanderbilt UniversityProduct Specifications
Molecular Weight
575.15
Formula
C34H38N2O4.HCl
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid hydrochloride
CAS Number
2416138-42-4
PubChem ID
145710038
InChI Key
LUQMUDMPRZSZTJ-YNMZEGNTSA-N
SMILES
CC1=CC=CC(COC(C=CC=C2)=C2CN(CC[C@H](N)C(O)=O)CC3=C(C=CC=C3)OCC4=CC(C)=CC=C4)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.76 | 50 with gentle warming | |
| Ethanol | 28.76 | 50 with gentle warming |
Preparing Stock Solutions
for V 9302 hydrochloride
The following data is based on the product molecular weight 575.15
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.48 mL | 17.39 mL | 34.77 mL |
| 2.5 mM | 0.70 mL | 3.48 mL | 6.95 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Park V-9302 inhibits proliferation and migration of VSMCs, and reduces neointima formation in mice after carotid artery ligation. Biochem.Biophys.Res.Commun. 2021 PMID: 33965788
- Li Inhibitor of glutamine metabolism V9302 promotes ROSinduced autophagic degradation of B7H3 to enhance antitumor immunity. J.Biol.Chem. 2022 PMID: 35189139
- Schulte Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat.Med. 2018 PMID: 29334372
Product Specific Notices for V 9302 hydrochloride
For research use only
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