Urocortin (human)

Name: Urocortin (human)
Brand: Tocris Bioscience
SKU: 1604

Tocris Bioscience, part of Bio-Techne | Catalog # 1604

Citations (1)

COA / SDS

Endogenous CRF agonist

Key Product Details

Description:	Endogenous CRF agonist
Purity:	≥95% (HPLC)
Molecular Weight:	4696.29

View Full Technical Details for Urocortin (human)

Technical Data
Citations

Biological Activity for Urocortin (human)

Urocortin (human) is an endogenous CRF agonist. K_i values are 0.4, 0.3 and 0.5 nM for hCRF₁, rCRF₂_α and mCRF₂_β respectively.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for Urocortin (human)

M. Wt	4696.29
Formula	C₂₀₄H₃₃₇N₆₃O₆₄
Single Letter Sequence	DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV (Modifications: Val-40 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	176591-49-4
PubChem ID	24868180
InChi Key	BIIOOWPFSOAZSO-WODJFTBTSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Urocortin (human)

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Urocortin (human)

References are publications that support the biological activity of the product.

Reul and Holsboer Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr.Opin.Pharmacol. 2002 PMID: 11786305
Skelton The neurobiology of urocortin. Regul.Pept. 2000 PMID: 11033056
Perrin and Vale Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 1999 PMID: 10816663