UNC 6852
Tocris Bioscience, part of Bio-Techne | Catalog # 7816
Polycomb repressive complex 2 (PRC2) Degrader (PROTAC®)
Key Product Details
Description
Polycomb repressive complex 2 (PRC2) Degrader (PROTAC®)
Product Description
UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC®; DC50 = 0.79 μM). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC50 = 0.31 μM, Dmax = 94%), enhancer of zeste homolog 2 (EZH2, DC50 = 0.67 μM, Dmax = 96%), and suppressor of zeste homolog 12 (SUZ12, DC50 = 0.59 μM, Dmax = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
832.98
Formula
C43H48N10O6S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2688842-08-0
PubChem ID
146014466
InChI Key
PPNNFXIBKLCMTI-WXEAQWFJSA-N
SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCNC(C(C=C4)=CC=C4C5=CN=C(N6C5=NN=C6)NCC7=CC=CO7)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 83.3 | 100 |
Preparing Stock Solutions
for UNC 6852
The following data is based on the product molecular weight 832.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.20 mL | 6.00 mL | 12.01 mL |
| 5 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 10 mM | 0.12 mL | 0.60 mL | 1.20 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Raman Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci.Rep. 2021 PMID: 34315984
- Potjewyd Degradation of polycomb repressive complex 2 with an EED-targeted bivalent chemical degrader. Cell Chem.Biol. 2020 PMID: 31831267
Product Specific Notices for UNC 6852
For research use only
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