UNC 3230

Name: UNC 3230
Brand: Tocris Bioscience
SKU: 5271

Tocris Bioscience a Bio-Techne Brand

Catalog # 5271

Citations (1)

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Key Product Details

Description:	Potent and selective PIP5K1C inhibitor; antinociceptive
Chemical Name:	5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	344.43

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Biological Activity for UNC 3230

UNC 3230 is a potent and selective PIP5K1C inhibitor (IC₅₀ = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP₂ levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

Compound Libraries for UNC 3230

UNC 3230 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for UNC 3230

M. Wt	344.43
Formula	C₁₇H₂₀N₄O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1031602-63-7
PubChem ID	46355372
InChi Key	RZCNASHHHSKTGP-UHFFFAOYSA-N
Smiles	O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 3230

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.44	100

Preparing Stock Solutions for UNC 3230

The following data is based on the product molecular weight 344.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.52 mL	29.03 mL
5 mM	0.58 mL	2.90 mL	5.81 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for UNC 3230

References are publications that support the biological activity of the product.

Wright The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 2014 PMID: 24853942

Citations for UNC 3230 (1)

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Citations are publications that use Bio-Techne products. Selected citations for UNC 3230 include:

Peng et al. (2019) Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine. 2019;
PMID: 31105034

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