UNC 1215, acid
Tocris Bioscience, part of Bio-Techne | Catalog # 7759
Functionalized L3MBTL3 ligand for PROTACs
Key Product Details
Description
Functionalized L3MBTL3 ligand for PROTACs
Product Description
UNC 1215, acid is a functionalized L3MBTL3 ligand for PROTAC® research and development. L3MBTL3-recruiting PROTACs induce nuclear-specific protein degradation of target proteins, such as FKBP12(F36V) and BRD2. UNC 1215, acid contains a carboxylic acid handle ready for conjugation to a target protein ligand.Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
801.78
Formula
C33H43N5O4.2CF3CO2H
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
4-[[2,5-Bis[[4-(1-pyrrolidinyl)-1-piperidinyl]carbonyl]phenyl]amino]benzoic acid ditrifluoroacetate
InChI Key
FONQYEMRSJVSSN-UHFFFAOYSA-N
SMILES
OC(C1=CC=C(NC2=C(C=CC(C(N3CCC(CC3)N4CCCC4)=O)=C2)C(N5CCC(CC5)N6CCCC6)=O)C=C1)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nalawansha Hijacking methyl reader proteins for nuclear-specific protein degradation. J.Am.Chem.Soc. 2022 PMID: 35311258
Product Specific Notices for UNC 1215, acid
For research use only
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