UNC 1215, acid

Name: UNC 1215, acid
Brand: Tocris Bioscience
SKU: 7759

Tocris Bioscience, part of Bio-Techne | Catalog # 7759

COA / SDS

Functionalized L3MBTL3 ligand for PROTACs

Key Product Details

Description:	Functionalized L3MBTL3 ligand for PROTACs
Chemical Name:	4-[[2,5-Bis[[4-(1-pyrrolidinyl)-1-piperidinyl]carbonyl]phenyl]amino]benzoic acid ditrifluoroacetate
Purity:	≥95% (HPLC)
Molecular Weight:	801.78

View Full Technical Details for UNC 1215, acid

Technical Data
Citations

Biological Activity for UNC 1215, acid

UNC 1215, acid is a functionalized L3MBTL3 ligand for PROTAC^® research and development. L3MBTL3-recruiting PROTACs induce nuclear-specific protein degradation of target proteins, such as FKBP12(F36V) and BRD2. UNC 1215, acid contains a carboxylic acid handle ready for conjugation to a target protein ligand.

Part of a range of functionalized tool molecules for PROTAC^&reg Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for UNC 1215, acid

M. Wt	801.78
Formula	C₃₃H₄₃N₅O₄.2CF₃CO₂H
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	FONQYEMRSJVSSN-UHFFFAOYSA-N
Smiles	OC(C1=CC=C(NC2=C(C=CC(C(N3CCC(CC3)N4CCCC4)=O)=C2)C(N5CCC(CC5)N6CCCC6)=O)C=C1)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for UNC 1215, acid

References are publications that support the biological activity of the product.

Nalawansha Hijacking methyl reader proteins for nuclear-specific protein degradation. J.Am.Chem.Soc. 2022 PMID: 35311258