UNC 0224
Tocris Bioscience, part of Bio-Techne | Catalog # 3861
Potent G9a and GLP inhibitor
Product Description
UNC 0224 is a potent G9a and GLP inhibitor (IC50 values are 15 and 20 nM in a ThioGlo assay, respectively). Exhibits >1000-fold selectivity for G9a over SET7, SET8 and SET9. UNC 0224 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.Product Specifications
Molecular Weight
485.67
Formula
C26H43N7O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
CAS Number
1197196-48-7
PubChem ID
44251522
InChI Key
XIVUGRBSBIXXJE-UHFFFAOYSA-N
SMILES
CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 48.57 | 100 | |
| DMSO | 48.57 | 100 |
Preparing Stock Solutions
for UNC 0224
The following data is based on the product molecular weight 485.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.30 mL | 20.59 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Guan Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 2022 PMID: 35418683
- Liu Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem. 2009 PMID: 19891491
Product Specific Notices for UNC 0224
For research use only
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