UK 383367

Name: UK 383367
Brand: Tocris Bioscience
SKU: 4188

Tocris Bioscience, part of Bio-Techne | Catalog # 4188

Citations (2)

COA / SDS

Potent and selective BMP-1 (PCP) inhibitor

Key Product Details

Description:	Potent and selective BMP-1 (PCP) inhibitor
Chemical Name:	3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	324.38

View Full Technical Details for UK 383367

Technical Data
Citations

Biological Activity for UK 383367

UK 383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC₅₀ = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC₅₀ values are >10,000 nM for listed MMPs).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for UK 383367

UK 383367 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UK 383367

M. Wt	324.38
Formula	C₁₅H₂₄N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	348622-88-8
PubChem ID	9818682
InChi Key	ARJCBSRIPGJMAD-LLVKDONJSA-N
Smiles	ONC(C[C@H](C2=NC(C(N)=O)=NO2)CCCC1CCCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 383367

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.44	100

Preparing Stock Solutions for UK 383367

The following data is based on the product molecular weight 324.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for UK 383367

References are publications that support the biological activity of the product.

Fish Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 2007 PMID: 17591762
Bailey Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 2008 PMID: 18945617
Allan Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 2006 PMID: 16854779