UK 383367
Tocris Bioscience, part of Bio-Techne | Catalog # 4188
Potent and selective BMP-1 (PCP) inhibitor
Key Product Details
Description
Potent and selective BMP-1 (PCP) inhibitor
Product Description
UK 383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
324.38
Formula
C15H24N4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
CAS Number
348622-88-8
PubChem ID
9818682
InChI Key
ARJCBSRIPGJMAD-LLVKDONJSA-N
SMILES
ONC(C[C@H](C2=NC(C(N)=O)=NO2)CCCC1CCCCC1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.44 | 100 |
Preparing Stock Solutions
for UK 383367
The following data is based on the product molecular weight 324.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fish Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 2007 PMID: 17591762
- Bailey Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 2008 PMID: 18945617
- Allan Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 2006 PMID: 16854779
Product Specific Notices for UK 383367
For research use only
Loading...
Loading...