UH15-38

Name: UH15-38
Brand: Tocris Bioscience
SKU: 8104

Tocris Bioscience, part of Bio-Techne | Catalog # 8104

COA / SDS

Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis

Key Product Details

Description:	Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
Chemical Name:	3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	514.45

View Full Technical Details for UH15-38

Technical Data
Citations

Biological Activity for UH15-38

UH15-38 is a potent and selective receptor interacting protein kinase 3 (RIPK3) inhibitor (IC₅₀ = 20 nM). UH15-38 potently and selectively blocks influenza A-induced necroptosis in alveolar epithelial cells in vivo (IC₅₀ = 39.5 nM), and prevents damage from lung inflammation without compromising antiviral adaptive immune responses or impeding viral clearance. Blocks TNFα-induced necroptosis in primary murine embryonic fibroblasts (IC₅₀ = 98 nM) and mouse cell lines in vitro.

Licensing Information

Sold under license from Tufts University

Scientific Data Examples for UH15-38

	Published vs Bio-Techne batch comparison for UH15-38. Inhibition of necroptosis by UH15-38 in human FADD-deficient Jurkat cells. Cells were treated with 10 ng/ml of human TNF alpha for 24 hr in the presence of the dose range of the inhibitors. Cell viability was determined using CellTiter-Glo assay (Promega). IC₅₀ for the published molecule was 238.2 nM and 160.2 nM for the Bio-Techne batch. Data kindly provided by A. Degterev’s laboratory, University of Tufts.

Technical Data for UH15-38

M. Wt	514.45
Formula	C₂₆H₂₇N₅O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	HIVPDYQXZCXJQM-UHFFFAOYSA-N
Smiles	O=C1C(C2=CC=CC(O)=C2)=CC3=C(N1C)C=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UH15-38

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.44	100
	water	51.44	100

Preparing Stock Solutions for UH15-38

The following data is based on the product molecular weight 514.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.72 mL	19.44 mL
5 mM	0.39 mL	1.94 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for UH15-38

References are publications that support the biological activity of the product.

Gautam Necroptosis blockade prevents lung injury in severe influenza. Nature 2024 PMID: 38600381