UCL 1684

Tocris Bioscience, part of Bio-Techne | Catalog # 1310

Highly potent KCa2 (SK) channel blocker
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Key Product Details

Description

Highly potent KCa2 (SK) channel blocker

View all Ca2+-Activated Potassium Channel Blockers »

Product Description

UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively.

Licensing Information

Sold with the permission of University College, London

Product Specifications

Molecular Weight

654.44

Formula

C34H30Br2N4

Storage

Desiccate at RT

Purity

≥97% (HPLC)

Chemical Name

6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide

CAS Number

199934-16-2

PubChem ID

9852584

InChI Key

KPNMQIKQVCWNTP-UHFFFAOYSA-N

SMILES

C12=CC=CC=C1C(NCC4=CC=C(CNC5=CC=[N+]7C6=C5C=CC=C6)C=C4)=CC=[N+]2CC3=CC=CC(C7)=C3.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.21 10

Preparing Stock Solutions for UCL 1684

The following data is based on the product molecular weight 654.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.28 mL 76.40 mL 152.80 mL
0.5 mM 3.06 mL 15.28 mL 30.56 mL
1 mM 1.53 mL 7.64 mL 15.28 mL
5 mM 0.31 mL 1.53 mL 3.06 mL

Calculators

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Reconstitution Calculator

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Product Documents for UCL 1684

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UCL 1684

For research use only

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