UCB 9386

Name: UCB 9386
Brand: Tocris Bioscience
SKU: 8914

Tocris Bioscience, part of Bio-Techne | Catalog # 8914

COA / SDS

Potent and selective CNS penetrant NUAK1 inhibitor

Key Product Details

Description:	Potent and selective CNS penetrant NUAK1 inhibitor
Chemical Name:	(R)-7-(Imidazo[1,2-b]pyridazin-3-yl)-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-1-(1-phenylethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	478.56

View Full Technical Details for UCB 9386

Technical Data
Citations

Biological Activity for UCB 9386

UCB 9386 is a potent and selective central nervous system penetrant NUAK1 (NUAK family SnF1-like kinase-1) inhibitor (pIC₅₀= 10.1). Kinome selectivity measured in the diversity panel shows that only Jak2 and Nuak2 are inhibited more than 50% at 10 nM. In vivo, UCB 9386 exhibits high brain penetrance.

Technical Data for UCB 9386

M. Wt	478.56
Formula	C₂₇H₂₆N₈O
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	172676957
InChi Key	XYKISMBNQVUKPW-GOSISDBHSA-N
Smiles	C[C@@H](N1C(C(N2CC3(C2)CN(C3)C)=NC4=C1C=C(C5=CN=C6C=CC=NN65)N=C4)=O)C7=CC=CC=C7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UCB 9386

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.86	100
	ethanol	47.86	100

Preparing Stock Solutions for UCB 9386

The following data is based on the product molecular weight 478.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.90 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for UCB 9386

References are publications that support the biological activity of the product.

Poullennec Discovery of UCB9386: a potent, selective, and brain-penetrant Nuak1 inhibitor suitable for in vivo pharmacological studies. J Med Chem 2024 PMID: 39588908