UC 112

Tocris Bioscience, part of Bio-Techne | Catalog # 5251

IAP and XIAP inhibitor; antitumor
Discontinued Product
5251 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description

IAP and XIAP inhibitor; antitumor

View all Apoptosis Inducer Compounds »

Product Description

UC 112 is an iAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

Product Specifications

Molecular Weight

348.44

Formula

C22H24N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

CAS Number

383392-66-3

PubChem ID

3426979

InChI Key

LTGLGIQQZXSLLF-UHFFFAOYSA-N

SMILES

OC1=C3C(C=CC=N3)=C(COCC4=CC=CC=C4)C=C1CN2CCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.84 100

Preparing Stock Solutions for UC 112

The following data is based on the product molecular weight 348.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.70 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for UC 112

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UC 112

For research use only

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