UBP 310

Name: UBP 310
Brand: Tocris Bioscience
SKU: 3621

Tocris Bioscience, part of Bio-Techne | Catalog # 3621

Citations (22)

COA / SDS

GluK1-selective kainate antagonist

Key Product Details

Description:	GluK1-selective kainate antagonist
Chemical Name:	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Purity:	≥98% (HPLC)
Molecular Weight:	353.35

View Full Technical Details for UBP 310

Technical Data
Citations

Biological Activity for UBP 310

UBP 310 is a GluK1 (formerly GLU_K5) kainate receptor antagonist (IC₅₀ = 130 nM); also blocks recombinant homomeric GluK3 (forrmerly GLU_K7) receptors. Displays 12,700-fold selectivity for GluK1 (formerly GLU_K5) over GluK2 (formerly GLU_K6). Exhibits no activity at mGlu group I or NMDA receptors at concentrations of up to 10 μM. Apparent K_D value is 18 ± 4 nM for depression of kainate responses on the dorsal root.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for UBP 310

UBP 310 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UBP 310

M. Wt	353.35
Formula	C₁₄H₁₅N₃O₆S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	902464-46-4
PubChem ID	6420160
InChi Key	ZTAZUCRXCRXNSU-VIFPVBQESA-N
Smiles	CC1=CN(C[C@@H](C(O)=O)N)C(N(CC2=C(C(O)=O)SC=C2)C1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UBP 310

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.07	20

Preparing Stock Solutions for UBP 310

The following data is based on the product molecular weight 353.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.15 mL	70.75 mL	141.50 mL
1 mM	2.83 mL	14.15 mL	28.30 mL
2 mM	1.42 mL	7.08 mL	14.15 mL
10 mM	0.28 mL	1.42 mL	2.83 mL

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References for UBP 310

References are publications that support the biological activity of the product.

Dolman Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: Role of the substituent at the 5-position of the uracil ring in development of highly potent and selective GLUK5 kainate receptor antagonists. J.Med.Chem. 2007 PMID: 17348638
Perrais Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 2009 PMID: 18761361
Mayer Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J.Neurosci. 2006 PMID: 16540562