TTP 22

Name: TTP 22
Brand: Tocris Bioscience
SKU: 4432

Tocris Bioscience, part of Bio-Techne | Catalog # 4432

Citations (9)

COA / SDS

High affinity, selective CK2 inhibitor

Key Product Details

Description:	High affinity, selective CK2 inhibitor
Chemical Name:	3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	330.42

View Full Technical Details for TTP 22

Technical Data
Citations

Biological Activity for TTP 22

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC₅₀ = 0.1 μM, K_i = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).

Compound Libraries for TTP 22

TTP 22 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TTP 22

M. Wt	330.42
Formula	C₁₆H₁₄N₂O₂S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	329907-28-0
PubChem ID	1536915
InChi Key	RAOULLCLLOGTDA-UHFFFAOYSA-N
Smiles	CC(C=C3)=CC=C3C1=CSC2=C1C(SCCC(O)=O)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TTP 22

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.04	100
	ethanol	6.61	20

Preparing Stock Solutions for TTP 22

The following data is based on the product molecular weight 330.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.26 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for TTP 22

References are publications that support the biological activity of the product.

Golub Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 2011 PMID: 21276643