TRPV3 74a
Tocris Bioscience, part of Bio-Techne | Catalog # 6831
Selective TRPV3 antagonist; brain penetrant
Key Product Details
Description
Selective TRPV3 antagonist; brain penetrant
Product Description
TRPV3 74a is a selective TRPV3 antagonist (KB = 0.56 μM). Displays no significant activity against a panel of other ion channels. Exhibits efficacy in animal models of neuropathic pain. Brain penetrant.Product Specifications
Molecular Weight
338.32
Formula
C17H17F3N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
CAS Number
1432051-63-2
PubChem ID
71554840
InChI Key
MTJXDHFAWXGXIN-OAGGEKHMSA-N
SMILES
C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.83 | 100 |
Preparing Stock Solutions
for TRPV3 74a
The following data is based on the product molecular weight 338.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.56 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.30 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gomtsyan Synthesis and pharmacology of (pyridin-2-yl)methanol derivatives as novel and selective transient receptor potential vanilloid 3 antagonists. J.Med.Chem. 2016 PMID: 27077528
Product Specific Notices for TRPV3 74a
For research use only
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