Tropisetron hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2459

Potent 5-HT3 antagonist; also α7 nAChR partial agonist
Catalog #
Availability
Size / Price
Qty
2459/10
2459/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Potent 5-HT3 antagonist; also α7 nAChR partial agonist

Alternative Names

Novaban,ICS 205930

View all 5-HT3 Receptor Antagonists »

Product Description

Tropisetron hydrochloride is a potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7Q79G-GlyR chimeric ion channels (EC50 = 38 nM)

Product Specifications

Molecular Weight

320.82

Formula

C17H20N2O2.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride

CAS Number

105826-92-4

PubChem ID

656664

InChI Key

XIEGSJAEZIGKSA-KOQCZNHOSA-N

SMILES

O=C(O[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)C2=CNC1=CC=CC=C12.O=C(O[C@@H]7C[C@H]8CC[C@H](N8C)C7)C6=CNC5=CC=CC=C56.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 32.08 100
DMSO 16.04 50

Preparing Stock Solutions for Tropisetron hydrochloride

The following data is based on the product molecular weight 320.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.59 mL 31.17 mL
5 mM 0.62 mL 3.12 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Tropisetron hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tropisetron hydrochloride

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.