Trofinetide
Tocris Bioscience, part of Bio-Techne | Catalog # 7937
IGF-1 synthetic analogue
Key Product Details
Description
IGF-1 synthetic analogue
Product Description
Trofinetide is an IGF-1 synthetic analog. It suppresses expression of IL-1β, TNF-α, IFN-γ and E-selectin, and inhibits both acute and delayed neuroinflammation following penetrating ballistic-like brain injury (PBBI) in rats.Product Specifications
Molecular Weight
315.32
Formula
C13H21N3O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Glycyl-2-methyl-L-prolyl-L-glutamic acid
CAS Number
853400-76-7
InChI Key
BUSXWGRAOZQTEY-SDBXPKJASA-N
SMILES
C(N[C@@H](CCC(O)=O)C(O)=O)(=O)[C@@]1(C)N(C(CN)=O)CCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.53 | 100 | |
| DMSO | 15.77 | 50 with gentle warming |
Preparing Stock Solutions
for Trofinetide
The following data is based on the product molecular weight 315.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.17 mL | 15.86 mL | 31.71 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.34 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.17 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wei NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J.Neuroinflammation 2009 PMID: 19656406
Product Specific Notices for Trofinetide
For research use only
Loading...
Loading...