TRO 19622
Tocris Bioscience, part of Bio-Techne | Catalog # 2906
Binds voltage-dependent anion channel (VDAC)
Key Product Details
Description
Binds voltage-dependent anion channel (VDAC)
Alternative Names
Olesoxime
Product Description
TRO 19622 is a neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.Product Specifications
Molecular Weight
399.65
Formula
C27H45NO
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
Cholest-4-en-3-one oxime
CAS Number
22033-87-0
PubChem ID
76971721
InChI Key
QNTASHOAVRSLMD-GYKMGIIDSA-N
SMILES
[H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.98 | 50 | |
| Ethanol | 7.99 | 20 |
Preparing Stock Solutions
for TRO 19622
The following data is based on the product molecular weight 399.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.00 mL | 25.02 mL | 50.04 mL |
| 2.5 mM | 1.00 mL | 5.00 mL | 10.01 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 25 mM | 0.10 mL | 0.50 mL | 1.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bordet Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 2007 PMID: 17496168
Product Specific Notices for TRO 19622
For research use only
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