tri-GalNAc-PEG3-Azide
Tocris Bioscience, part of Bio-Techne | Catalog # 8015
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
Key Product Details
Description
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
Product Description
tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.Product Specifications
Molecular Weight
1644.83
Formula
C70H125N13O31
Storage
Store at -20°C
Purity
≥90% (HPLC)
CAS Number
2925590-71-0
InChI Key
QNGSUVMZQPQMPB-CNCRQLPOSA-N
SMILES
OC[C@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)O[C@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5 |
Preparing Stock Solutions
for tri-GalNAc-PEG3-Azide
The following data is based on the product molecular weight 1644.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.04 mM | 15.20 mL | 76.00 mL | 151.99 mL |
| 0.2 mM | 3.04 mL | 15.20 mL | 30.40 mL |
| 0.4 mM | 1.52 mL | 7.60 mL | 15.20 mL |
| 2 mM | 0.30 mL | 1.52 mL | 3.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sanhueza Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 2017 PMID: 28230359
Product Specific Notices for tri-GalNAc-PEG3-Azide
For research use only
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