TRAP-6

Tocris Bioscience a Bio-Techne Brand

Catalog # 3497

Citations (6)

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Key Product Details

Description:	PAR₁ peptide fragment (residues 42-47); acts as a PAR₁ agonist
Alternative Names:	Thrombin receptor activator peptide 6
Purity:	≥95% (HPLC)
Molecular Weight:	748.88

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Biological Activity for TRAP-6

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR₁) that acts as a PAR₁ agonist. Stimulates platelet aggregation (EC₅₀ = 0.8 μM), promotes intracellular Ca²⁺ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data for TRAP-6

M. Wt	748.88
Formula	C₃₄H₅₆N₁₀O₉
Single Letter Sequence	SFLLRN
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	141136-83-6
PubChem ID	9831933
InChi Key	HAGOWCONESKMDW-FRSCJGFNSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRAP-6

Solubility

Soluble to 1mg/ml in water

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References for TRAP-6

References are publications that support the biological activity of the product.

Hunter Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 2009 PMID: 19261611
Kaufmann PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 1999 PMID: 10421070
Vassallo Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 1992 PMID: 1313429

Citations for TRAP-6 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for TRAP-6 include:

Elenbaas et al. (2023) SVEP1 is an endogenous ligand for the orphan receptor PEAR1 Nat Commun. 14:850
PMID: 36792666
Gockel et al. (2018) The Low Molecular Weight HP Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways. Molecules. 23
PMID: 30356007
Ponert et al. (2018) Unfractionated and Low Molecular Weight HP Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells. Molecules. 23
PMID: 30347648
Dhenge et al. (2017) Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells. Cell Cycle. 16:979
PMID: 28388313
Tripathi et al. (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 55:3912
PMID: 24876278
Yan et al. (2013) Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Front Bioeng Biotechnol. 44:1410
PMID: 23539525

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Showing 1 - 6 of 6 citations Showing All

Product Documents for TRAP-6

COA

Certificate of Analysis

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