TP 472
Tocris Bioscience, part of Bio-Techne | Catalog # 6000
Potent BRD9/7 inhibitor
Product Description
TP 472 is a potent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.Negative Control also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.Product Specifications
Molecular Weight
333.38
Formula
C20H19N3O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
CAS Number
2079895-62-6
PubChem ID
123773279
InChI Key
RPBMXJHQYJLPDN-UHFFFAOYSA-N
SMILES
O=C(C)C1=CC(C2=CC(C(NC3CC3)=O)=CC=C2C)=C4N=CC=CN41
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.67 | 50 |
Preparing Stock Solutions
for TP 472
The following data is based on the product molecular weight 333.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.00 mL | 30.00 mL | 59.99 mL |
| 2.5 mM | 1.20 mL | 6.00 mL | 12.00 mL |
| 5 mM | 0.60 mL | 3.00 mL | 6.00 mL |
| 25 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hohmann and Vakoc A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 2014 PMID: 24932742
Product Specific Notices for TP 472
For research use only
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