TP-040

Name: TP-040
Brand: Tocris Bioscience
SKU: 7771

Tocris Bioscience, part of Bio-Techne | Catalog # 7771

Citations (3)

COA / SDS

Potent and selective O-GlcNAcase (OGA) inhibitor

Key Product Details

Description:	Potent and selective O-GlcNAcase (OGA) inhibitor
Chemical Name:	N-[(1-Methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	286.38

View Full Technical Details for TP-040

Technical Data
Citations

Biological Activity for TP-040

TP-040 is a potent and selective O-GlcNAcase (OGA) inhibitor (IC₅₀ = 46 nM). It increases the level of O-GlcNAcylated protein in human neuroblastoma SH-SY5Y cells (EC₅₀ = 450 nM). It is suitable for in vivo studies and exhibits brain permeability.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP-040 probe summary on the SGC website.

Technical Data for TP-040

M. Wt	286.38
Formula	C₁₅H₂₂N₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2757254-99-0
PubChem ID	162640825
InChi Key	PWKAYICUBVNJAZ-UHFFFAOYSA-N
Smiles	CN1C=NC(CNC2=NC=CC(N3CCC(CC3)C)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TP-040

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	28.64	100
	DMSO	28.64	100

Preparing Stock Solutions for TP-040

The following data is based on the product molecular weight 286.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.46 mL	34.92 mL
5 mM	0.70 mL	3.49 mL	6.98 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for TP-040

References are publications that support the biological activity of the product.

Tawada Discovery of a novel and brain-penetrant O-GlcNAcase inhibitor via virtual screening, structure-based analysis, and rational lead optimization. J.Med.Chem. 2021 PMID: 33404239