Tomoxetine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2011
Potent and selective noradrenalin re-uptake inhibitor
Key Product Details
Description
Potent and selective noradrenalin re-uptake inhibitor
Alternative Names
Atomoxetine,LY 139603
Product Description
Tomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Antidepressant.Product Specifications
Molecular Weight
291.82
Formula
C17H21NO.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
CAS Number
82248-59-7
PubChem ID
54840
InChI Key
LUCXVPAZUDVVBT-UNTBIKODSA-N
SMILES
Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.59 | 50 with gentle warming |
Preparing Stock Solutions
for Tomoxetine hydrochloride
The following data is based on the product molecular weight 291.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.85 mL | 34.27 mL | 68.54 mL |
| 2.5 mM | 1.37 mL | 6.85 mL | 13.71 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.85 mL |
| 25 mM | 0.14 mL | 0.69 mL | 1.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bymaster Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 2002 PMID: 12431845
- Wong A new inhibitor of NE uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 1982 PMID: 6123593
Product Specific Notices for Tomoxetine hydrochloride
For research use only
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