Tomoxetine hydrochloride

Name: Tomoxetine hydrochloride
Brand: Tocris Bioscience
SKU: 2011
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2011

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Citations (593)

COA / SDS

Potent and selective noradrenalin re-uptake inhibitor

Key Product Details

Description:	Potent and selective noradrenalin re-uptake inhibitor
Alternative Names:	Atomoxetine,LY 139603
Chemical Name:	(R)-N-Methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	291.82

View Full Technical Details for Tomoxetine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Tomoxetine hydrochloride

Tomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (K_i values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (K_i > 1 μM). Antidepressant.

Technical Data for Tomoxetine hydrochloride

M. Wt	291.82
Formula	C₁₇H₂₁NO.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	82248-59-7
PubChem ID	54840
InChi Key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Smiles	Cl[H].CNCC[C@@H](OC1=C(C)C=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tomoxetine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	14.59	50 with gentle warming

Preparing Stock Solutions for Tomoxetine hydrochloride

The following data is based on the product molecular weight 291.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.85 mL	34.27 mL	68.54 mL
2.5 mM	1.37 mL	6.85 mL	13.71 mL
5 mM	0.69 mL	3.43 mL	6.85 mL
25 mM	0.14 mL	0.69 mL	1.37 mL

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References for Tomoxetine hydrochloride

References are publications that support the biological activity of the product.

Bymaster Atomoxetine increases extracellular levels of NE and DA in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 2002 PMID: 12431845
Wong A new inhibitor of NE uptake devoid of affinity for receptors in rat brain. J.Pharmacol.Exp.Ther. 1982 PMID: 6123593