Tolcapone
Tocris Bioscience, part of Bio-Techne | Catalog # 5864
COMT inhibitor; also inhibits transthyretin aggregation
Key Product Details
Description
COMT inhibitor; also inhibits transthyretin aggregation
Alternative Names
Tasmar,Ro 40-7592
Product Description
Tolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.Product Specifications
Molecular Weight
273.24
Formula
C14H11NO5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
CAS Number
134308-13-7
PubChem ID
4659569
InChI Key
MIQPIUSUKVNLNT-UHFFFAOYSA-N
SMILES
OC1=C(O)C([N+]([O-])=O)=CC(C(C2=CC=C(C)C=C2)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.32 | 100 | |
| Ethanol | 27.32 | 100 |
Preparing Stock Solutions
for Tolcapone
The following data is based on the product molecular weight 273.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.66 mL | 18.30 mL | 36.60 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Männistö Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. Br.J.Pharmacol. 1992 PMID: 1628144
- Sant'Anna Repositioning tolc. as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nat.Commun. 2016 PMID: 26902880
Product Specific Notices for Tolcapone
For research use only
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