TMN 355
Tocris Bioscience, part of Bio-Techne | Catalog # 4152
Cyclophilin A inhibitor
Discontinued Product
4152 has been discontinued.
View all Miscellaneous Compounds products.
Product Description
TMN 355 is a potent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).Product Specifications
Molecular Weight
380.80
Formula
C21H14ClFN2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
CAS Number
1186372-20-2
PubChem ID
44249042
InChI Key
SFNLLCUAISZNRV-UHFFFAOYSA-N
SMILES
ClC1=C(C(NC(NC2C(C=CC=C4)=C4C3=C2C=CC=C3)=O)=O)C(F)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.23 | 40 |
Preparing Stock Solutions
for TMN 355
The following data is based on the product molecular weight 380.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 6.57 mL | 32.83 mL | 65.65 mL |
| 2 mM | 1.31 mL | 6.57 mL | 13.13 mL |
| 4 mM | 0.66 mL | 3.28 mL | 6.57 mL |
| 20 mM | 0.13 mL | 0.66 mL | 1.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ni Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 2009 PMID: 19691347
Product Specific Notices for TMN 355
For research use only
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