Tiplaxtinin

Name: Tiplaxtinin
Brand: Tocris Bioscience
SKU: 5565

Tocris Bioscience, part of Bio-Techne | Catalog # 5565

Citations (8)

COA / SDS

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Key Product Details

Description:	Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Alternative Names:	PAI 039,tiplasinin
Chemical Name:	α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	439.38

View Full Technical Details for Tiplaxtinin

Technical Data
Citations

Biological Activity for Tiplaxtinin

Tiplaxtinin is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC₅₀ = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.

Compound Libraries for Tiplaxtinin

Tiplaxtinin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tiplaxtinin

M. Wt	439.38
Formula	C₂₄H₁₆F₃NO₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	393105-53-8
PubChem ID	6450819
InChi Key	ODXQFEWQSHNQNI-UHFFFAOYSA-N
Smiles	O=C(C(O)=O)C2=CN(CC3=CC=CC=C3)C1=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tiplaxtinin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.94	100
	ethanol	43.94	100

Preparing Stock Solutions for Tiplaxtinin

The following data is based on the product molecular weight 439.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.38 mL	22.76 mL
5 mM	0.46 mL	2.28 mL	4.55 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Tiplaxtinin

References are publications that support the biological activity of the product.

Simone A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell.Signal. 2015 PMID: 25617690
Elokdah Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J.Med.Chem. 2004 PMID: 15214776