Tiplaxtinin

Tocris Bioscience, part of Bio-Techne | Catalog # 5565

Plasminogen activator inhibitor-1 (PAI-1) inhibitor
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Key Product Details

Description

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Alternative Names

PAI 039,tiplasinin

View all PAI-1 Inhibitors »

Product Description

Tiplaxtinin is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.

Product Specifications

Molecular Weight

439.38

Formula

C24H16F3NO4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid

CAS Number

393105-53-8

PubChem ID

6450819

InChI Key

ODXQFEWQSHNQNI-UHFFFAOYSA-N

SMILES

O=C(C(O)=O)C2=CN(CC3=CC=CC=C3)C1=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.94 100
Ethanol 43.94 100

Preparing Stock Solutions for Tiplaxtinin

The following data is based on the product molecular weight 439.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.38 mL 22.76 mL
5 mM 0.46 mL 2.28 mL 4.55 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Documents for Tiplaxtinin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tiplaxtinin

For research use only

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