Tiotidine
Tocris Bioscience, part of Bio-Techne | Catalog # 0826
Potent and selective H2 antagonist
Key Product Details
Description
Potent and selective H2 antagonist
Alternative Names
ICI 125,211
Product Description
Tiotidine is a potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
312.41
Formula
C10H16N8S2
Storage
Store at RT
Purity
≥98% (HPLC)
CAS Number
69014-14-8
PubChem ID
50287
InChI Key
YDDXVAXDYKBWDX-UHFFFAOYSA-N
SMILES
CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 | ||
| Ethanol | 10 |
Preparing Stock Solutions
for Tiotidine
The following data is based on the product molecular weight 312.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.20 mL | 16.00 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.20 mL | 6.40 mL |
| 10 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Trzeciakowski and Levi The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 1980 PMID: 6105207
- Yellin ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 1979 PMID: 43449
- Hill Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693
Product Specific Notices for Tiotidine
For research use only
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