Tiotidine

Name: Tiotidine
Brand: Tocris Bioscience
SKU: 0826

Tocris Bioscience a Bio-Techne Brand

Catalog # 0826

Citations (5)

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Key Product Details

Description:	Potent and selective H₂ antagonist
Alternative Names:	ICI 125,211
Purity:	≥99% (HPLC)
Molecular Weight:	312.41

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Biological Activity for Tiotidine

Tiotidine is a potent histamine H₂-receptor antagonist with negligible activity against H₁- and H₃- receptors.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for Tiotidine

M. Wt	312.41
Formula	C₁₀H₁₆N₈S₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	69014-14-8
PubChem ID	50287
InChi Key	YDDXVAXDYKBWDX-UHFFFAOYSA-N
Smiles	CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tiotidine

	Solvent	Max Conc. mM
Solubility
	ethanol	10
	DMSO	100

Preparing Stock Solutions for Tiotidine

The following data is based on the product molecular weight 312.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.00 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for Tiotidine

References are publications that support the biological activity of the product.

Hill Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693
Trzeciakowski and Levi The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H₂- receptor antagonist. J.Pharmacol.Exp.Ther. 1980 PMID: 6105207
Yellin ICI 125,211: A new gastric antisecretory agent acting on histamine H₂- receptors. Life Sci. 1979 PMID: 43449

Citations for Tiotidine (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Tiotidine include:

Nagata et al. (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep. 9:16438
PMID: 31712714
Alonso et al. (2015) Physiological implications of biased signaling at histamine H2 receptors. Exp Ther Med. 6:45
PMID: 25805997
Chigaev et al. (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem. 286:20375
PMID: 21515675
Holden et al. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Front Pharmacol. 152:891
PMID: 17891168
Flamand et al. (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol. 141:552
PMID: 14744809

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