THIQ

Tocris Bioscience a Bio-Techne Brand

Catalog # 3032

Citations (3)

(1)

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Key Product Details

Description:	Potent and selective MC₄ receptor agonist
Chemical Name:	N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	589.17

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Biological Activity for THIQ

THIQ is a potent and selective melanocortin 4 (MC₄) receptor agonist (IC₅₀ values are 1.2, 761 and 2067 nM for human MC₄, MC₃ and MC₁ receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

Technical Data for THIQ

M. Wt	589.17
Formula	C₃₃H₄₁ClN₆O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	312637-48-2
PubChem ID	9938402
InChi Key	HLCHESOMJVGDSJ-LOYHVIPDSA-N
Smiles	O=[C@@]([C@H](NC([C@H]5CC(C=CC=C6)=C6CN5)=O)CC4=CC=C(Cl)C=C4)N1CCC(CN2N=CN=C2)(C3CCCCC3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for THIQ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.89	10

Preparing Stock Solutions for THIQ

The following data is based on the product molecular weight 589.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.97 mL	84.87 mL	169.73 mL
0.5 mM	3.39 mL	16.97 mL	33.95 mL
1 mM	1.70 mL	8.49 mL	16.97 mL
5 mM	0.34 mL	1.70 mL	3.39 mL

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References for THIQ

References are publications that support the biological activity of the product.

Mutulis New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J.Med.Chem. 2004 PMID: 15317471
Sebhat Design and pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-methyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective melanocorti J.Med.Chem. 2002 PMID: 12361385
Martin Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 2002 PMID: 12409007

Citations for THIQ (3)

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Citations are publications that use Bio-Techne products. Selected citations for THIQ include:

Garfield et al. (2015) A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 18:863
PMID: 25915476
Huang and Tao (2014) A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants. Front Pharmacol. 10:817
PMID: 25076858
Sohn et al. (2013) Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Int J Biol Sci. 152:612
PMID: 23374353

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Customer Reviews for THIQ (1)

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THIQ treatment increase social interactions

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Recently, we demonstrated that the deletion of the NFKB1 gene, which encodes the p50 NF-kappa B subunit, causes impairment in social behaviours, with reductions in social interactions in mice. In this work, we tested the acute effects of THIQ, a selective melanocortin 4 receptor (MC4R) agonist. THIQ treatment increased social interactions both in wild type and p50-/- mice. In particular, after treatment with THIQ, p50-/- mice showed a prosocial behaviour analogous to that of basal WT mice.

PMID: 29454840

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Product Documents for THIQ

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.