Thalidomide 4'-oxyacetamide-PEG2-amine
Tocris Bioscience, part of Bio-Techne | Catalog # 6967
Cereblon ligand with PEG linker and terminal amine for onward chemistry
Key Product Details
Description
Cereblon ligand with PEG linker and terminal amine for onward chemistry
Alternative Names
Thalidomide - linker 14
Product Description
Thalidomide 4'-oxyacetamide-PEG2-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker with ethylamine terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.This product has been recently renamed. The previous name for this product was Thalidomide - linker 14
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
498.92
Formula
C21H26N4O8.HCl
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
CAS Number
2376990-30-4
SMILES
NCCOCCOCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 24.95 | 50 | |
| DMSO | 24.95 | 50 |
Preparing Stock Solutions
for Thalidomide 4'-oxyacetamide-PEG2-amine
The following data is based on the product molecular weight 498.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.01 mL | 20.04 mL | 40.09 mL |
| 2.5 mM | 0.80 mL | 4.01 mL | 8.02 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.01 mL |
| 25 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for Thalidomide 4'-oxyacetamide-PEG2-amine
For research use only
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