Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Name: Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
Brand: Tocris Bioscience
SKU: 6913

Tocris Bioscience, part of Bio-Techne | Catalog # 6913

COA / SDS

Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry

Key Product Details

Description:	Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry
Chemical Name:	N-[3-[2-[2-(3-Aminopropoxy)ethoxy]ethoxy]propyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	571.02

View Full Technical Details for Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Technical Data
Citations

Biological Activity for Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus an alkylC1-PEG3-alkylC3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

M. Wt	571.02
Formula	C₂₅H₃₄N₄O₉.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2564466-93-7
Smiles	NCCCOCCOCCOCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

References are publications that support the biological activity of the product.

Nabet The dTAG system for immediate and target specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585