TG 003

Name: TG 003
Brand: Tocris Bioscience
SKU: 4336

Tocris Bioscience, part of Bio-Techne | Catalog # 4336

Citations (4)

COA / SDS

Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B

Key Product Details

Description:	Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B
Chemical Name:	(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
Purity:	≥98% (HPLC)
Molecular Weight:	249.33

View Full Technical Details for TG 003

Technical Data
Citations

Biological Activity for TG 003

TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC₅₀ values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC₅₀ values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

Compound Libraries for TG 003

TG 003 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TG 003

M. Wt	249.33
Formula	C₁₃H₁₅NO₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	719277-26-6
PubChem ID	647991
InChi Key	BGVLELSCIHASRV-UHFFFAOYSA-N
Smiles	O=C(C)/C=C1SC2=CC=C(OC)C=C2N\1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TG 003

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.93	100
	ethanol	18.7	75

Preparing Stock Solutions for TG 003

The following data is based on the product molecular weight 249.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.05 mL	40.11 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for TG 003

References are publications that support the biological activity of the product.

Foucourt Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 2014 PMID: 25264830
Muraki Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 2004 PMID: 15010457