Key Product Details
Description: | Na+ channel blocker |
Alternative Names: | TTx |
Chemical Name: | (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 319.27 |
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Citations for Tetrodotoxin (338)
Citations are publications that use Bio-Techne products. Selected citations for Tetrodotoxin include:
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Sabater et al.
(2021)
Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
J Neurosci.
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Maldonado et al.
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Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons.
Curr Biol.
31:322
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O'Malley et al.
(2020)
TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
J Neurosci.
40:4813
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Kramer et al.
(2020)
Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
ELIfe.
9
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Evans et al.
(2020)
Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
Cell Rep.
32
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Dorst et al.
(2020)
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Nat Commun.
11:5113
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Green and Thayer et al.
(2019)
HIV gp120 upregulates tonic inhibition through α5-containing GABAARs.
Neuropharmacology.
149:161
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Shen et al.
(2019)
Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins.
Science.
363:1303
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Bülow et al.
(2019)
Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
Cell Rep.
26:1378
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Nam et al.
(2019)
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Cell Rep.
28:1154
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Ye et al.
(2019)
KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission.
Neuropharmacology.
157
PMID: 31207251 -
Pierrot et al.
(2019)
Sex-regulated gene dosage effect of PPARα on synaptic plasticity.
Life Sci Alliance.
2
PMID: 30894406 -
Hui et al.
(2019)
GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior.
Sci Adv.
5:eaau8237
PMID: 30989111 -
Rizzi and Tan
(2019)
Synergistic Nigral Output Pathways Shape Movement.
Cell Rep.
27:2184
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Rhee et al.
(2019)
An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
Cell Rep.
27:2212
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Huang et al.
(2019)
Neural mechanisms of contextual modulation in the retinal direction selective circuit.
Nat Commun.
10:2431
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Ciappelloni et al.
(2019)
Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease.
Cell Rep.
27:3860
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Romanos et al.
(2019)
Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
Commun Biol.
2:127
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Yu et al.
(2019)
Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice.
Mol Brain.
12:29
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Roesler et al.
(2019)
Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.
Front Cell Neurosci.
13:330
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Zhu et al.
(2019)
Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.
Nat Commun.
10:3469
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Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
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Incontro
(2018)
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.
Nat Commun.
9:2069
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Zhang et al.
(2018)
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Neuron.
98:918
PMID: 29754751 -
Sun et al.
(2018)
OXT Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord.
Front Mol Neurosci.
11:248
PMID: 30065629 -
Purkey et al.
(2018)
AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Cell Rep.
25:974
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Smith et al.
(2018)
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Cell Rep.
25:278
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Li et al.
(2018)
Hypothalamic Circuits for Predation and Evasion.
Neuron.
97:911
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Fan et al.
(2018)
All-optical synaptic electrophysiology probes mechanism of KA-induced disinhibition.
Nat Methods.
15:823
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Fernandez-Fernandez et al.
(2018)
Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
PLoS One.
13:e0199282
PMID: 29928032 -
Zhong et al.
(2018)
Retinoic Acid Receptor RARα-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex.
J Neurosci.
38:10454
PMID: 30355624 -
Beas et al.
(2018)
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Nat Neurosci.
21:963
PMID: 29915192 -
Filipello et al.
(2018)
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Immunity.
48:979
PMID: 29752066 -
Sándor et al.
(2018)
Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles.
Front Pharmacol.
9:323
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Saxton et al.
(2018)
Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose Tissue.
Arterioscler Thromb Vasc Biol.
38:880
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Bellono
(2017)
Molecular basis of ancestral vertebrate electroreception.
Nature.
543:391
PMID: 28264196 -
Chen
(2017)
Methylene blue inhibits GABAA receptors by interaction with GABA binding site.
Neuropharmacology.
119:100
PMID: 28390894 -
Tuesta
(2017)
GLP-1 acts on habenular avoidance circuits to control nicotine intake.
Nat Neurosci.
20(5):708
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Wei et al.
(2017)
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions.
Sci Rep.
7:981
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Wang et al.
(2017)
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
J Clin Invest.
127:1978
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Lai et al.
(2017)
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Neuron.
95:591
PMID: 28772123 -
Guntupalli et al.
(2017)
GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
J Biol Chem.
292:8186
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Nagendran et al.
(2017)
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nat Commun.
8:625
PMID: 28931811 -
Hashimotodani et al.
(2017)
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron.
95:928
PMID: 28817805 -
Pollak et al.
(2017)
Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy.
PLoS One.
12:e0172884
PMID: 28264064 -
Sigler et al.
(2017)
Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.
Neuron.
94:304
PMID: 28426965 -
McKeithan et al.
(2017)
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Front Physiol.
8:766
PMID: 29075196 -
Klapper et al.
(2017)
On-demand optogenetic activation of human stem-cell-derived neurons.
Sci Rep.
7:14450
PMID: 29089561 -
Chang et al.
(2017)
CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca2+ Signals during LTP Induction, but Not Maintenance.
Neuron.
94:800
PMID: 28521133 -
Grochowska et al.
(2017)
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
EMBO Rep.
18:962
PMID: 28420656 -
Teotia et al.
(2017)
A Co-culture Model for Determining the Target Specificity of the de novo Generated Retinal Ganglion Cells.
Bio Protoc.
7
PMID: 28660235 -
Zhao et al.
(2017)
A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress.
Neuron.
95:138
PMID: 28625488 -
Leal et al.
(2017)
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.
Eneuro.
4
PMID: 29255796 -
Liu et al.
(2017)
IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
Neuron.
95:106
PMID: 28683263 -
Zhang and Lu
(2017)
Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
J Biol Chem.
292:15481
PMID: 28768764 -
Temkin et al.
(2017)
The Retromer Supports AMPA Receptor Trafficking During LTP.
Neuron.
94:74
PMID: 28384478 -
Bas-Orth et al.
(2017)
Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.
J Biol Chem.
292:5183
PMID: 28196867 -
Basu et al.
(2017)
Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus.
Neuron.
96:160
PMID: 28957665 -
Paul et al.
(2017)
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.
Cell.
171:522
PMID: 28942923 -
Prigge et al.
(2016)
M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina
The Journal of Neuroscience.
6:7184
PMID: 27383593 -
Miyamoto et al.
(2016)
Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
PLoS Pathog.
291:1719
PMID: 26589795 -
Borgs et al.
(2016)
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
Scientific Reports.
6:33377
PMID: 27640816 -
Borgs et al.
(2016)
DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific Reports.
6:33377
PMID: 27640816 -
Selten et al.
(2016)
Increased GABAB receptor signaling in a rat model for schizophrenia.
Scientific Reports.
6:34240
PMID: 27687783 -
Di Castro et al.
(2016)
The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area.
Scientific Reports.
6:34633
PMID: 27721466 -
Fan et al.
(2016)
Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.
Front Cell Neurosci.
10:74
PMID: 27047338 -
Gray and Golowasch
(2016)
Voltage Dependence of a Neuromodulator-Activated Ionic Current.
Eneuro.
3
PMID: 27257619 -
Beckley et al.
(2016)
The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens DA D1 Receptor Neurons.
J Neurosci.
36:701
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Savell et al.
(2016)
Extra-coding RNAs regulate neuronal DNA methylation dynamics.
Nat Commun.
7:12091
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Karaki et al.
(2016)
Effects of ε-viniferin, a dehydrodimer of resveratrol, on transepithelial active ion transport and ion permeability in the rat small and large intestinal mucosa.
Physiol Rep.
4
PMID: 27162263 -
Zhang et al.
(2016)
Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking.
J Biol Chem.
291:18856
PMID: 27417137 -
Havekes et al.
(2016)
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
J Neurosci.
36:8936
PMID: 27559174 -
Oberlander
(2016)
17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.
J Neurosci.
36:2677
PMID: 26937008 -
Wevers et al.
(2016)
High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.
Sci Rep.
6:38856
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Colavita et al.
(2016)
Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.
Sci Rep.
6:28454
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Mazzaro et al.
(2016)
Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.
J Neurosci.
36:2086
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Vidal et al.
(2016)
Cell-Autonomous Regulation of Dendritic Spine Density by PirB.
Eneuro.
3
PMID: 27752542 -
Mauger et al.
(2016)
Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Neuron.
92:1266
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Whitt et al.
(2016)
BK channel inactivation gates daytime excitability in the circadian clock.
Nat Commun.
7:10837
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Astorga et al.
(2015)
An excitatory GABA loop operating in vivo.
Front Cell Neurosci.
9:275
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Salvitti et al.
(2015)
No evidence for a culturable bacterial tetrodotoxin producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida).
Toxins (Basel).
7:255
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Jang et al.
(2015)
Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity.
Mol Brain.
8:55
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Noh et al.
(2015)
ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Proc Natl Acad Sci U S A.
112:6820
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Hou et al.
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MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
Nat Commun.
6:10045
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Lin et al.
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Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice.
Sci Rep.
5:12095
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Tang et al.
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Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
J Neurosci.
35:3016
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Cao et al.
(2015)
Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons.
Mar Drugs.
13:903
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Speed et al.
(2015)
Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits.
J Neurosci.
35:9648
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Xue et al.
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Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Proc Natl Acad Sci U S A.
112:E4316
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Kirwan et al.
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Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
Proc Natl Acad Sci U S A.
142:3178
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Bryant et al.
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Cholinergic control of γ power in the midbrain spatial attention network.
Mol Brain.
35:761
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Park et al.
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Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
J Biomed Sci.
8:7
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Wu et al.
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Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex.
Front Cell Neurosci.
22:94
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Scharinger et al.
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Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain.
J Cell Biol.
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Vossel et al.
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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
Elife.
209:419
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Saunders et al.
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Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Sci Rep.
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Asano et al.
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Optogenetic induction of contractile ability in immature C2C12 myotubes.
Curr Mol Med.
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Kano et al.
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Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.
Stem Cell Res Ther.
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Morini et al.
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Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
Front Cell Neurosci.
6:166
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Chen et al.
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Inhibitory effects of endomorphin-2 on excitatory synaptic transmission and the neuronal excitability of sacral parasympathetic preganglionic neurons in young rats.
J Neurosci.
9:206
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Ifrim et al.
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Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome.
Nat Neurosci.
35:7116
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Deidda et al.
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Early depolarizing GABA controls critical-period plasticity in the rat visual cortex.
J Neurosci.
18:87
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Campbell et al.
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Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
J Neurosci.
8:425
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Stephen et al.
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Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Nat Commun.
35:15996
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Zhang et al.
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Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity.
J Neurosci.
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Puranam et al.
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Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Mol Brain.
35:8866
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Lee et al.
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N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
J Neurosci.
8:4
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Ganley et al.
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Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
Front Synaptic Neurosci.
35:7626
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Born et al.
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Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors.
Mol Brain.
7:3
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Pál et al.
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Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
Front Cell Neurosci.
8:35
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Gao et al.
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Dendritic morphology, synaptic transmission, and activity of mature granule cells born following PilC-induced status epilepticus in the rat.
J Neurosci.
9:384
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Zhong et al.
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BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
J Neurosci.
35:4469
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Cramer et al.
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Mol Cell Biol.
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Wang et al.
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Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
PLoS One.
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Erlandson et al.
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The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation.
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Hooks et al.
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Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
Front Cell Neurosci.
35:4418
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Ghosh et al.
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NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
Cell Rep.
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Torper et al.
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In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry.
J Neurosci.
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Sobieski et al.
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Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
J Neurosci.
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Eyo et al.
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Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium.
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Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
Nat Commun.
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Virsolvy et al.
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Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranol.
Nat Commun.
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Laprell et al.
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Optical control of NMDA receptors with a diffusible photoswitch.
Sci Rep.
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Tang et al.
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Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
Stem Cells.
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Pisano et al.
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Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation.
Biomed Res Int.
33:1187
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Nguyen et al.
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Biological Activities of Tetrodotoxin-Producing Enterococcus faecium AD1 Isolated from Puffer Fishes.
Front Cell Neurosci.
2015:973235
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Yang et al.
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The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K(+) Channels.
Ann Clin Transl Neurol.
9:469
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Savtchenko et al.
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Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity.
PLoS One.
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Svalø et al.
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Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction.
J Neurosci.
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Witts et al.
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Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice.
PLoS One.
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Elgueta et al.
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Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
Physiol Rep.
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Cuthbert et al.
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Neural control of submucosal gland and apical membrane secretions in airways.
Oncotarget.
3
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Bernard and Zhang
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MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Eur J Neurosci.
10:e0124816
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Glykys and Staley
(2015)
D.pam effect during early neonatal development correlates with neuronal Cl(.).
J Cell Sci.
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Wiemhoefer et al.
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Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.
Mol Cell Proteomics.
14:2177
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Scudder and Patrick
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Customer Reviews for Tetrodotoxin (5)
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Species: MouseAssay Type: In VitroWorks great. Totally blocked the action potential in mouse brain slice.
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronal10 μM for 30min
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Species: OtherAssay Type: In VitroThe following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
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Species: RatAssay Type: Ex VivoCell Line/Tissue: HippocampusTetrodotoxin (TTX) was used to block action potential propagation in response to lasting current injection into living neuron. This illustrated a critical role of voltage-gated sodium channels in inter-neuronal crosstalk. 1 microM of TTX developed 100% effect (see Figure). Figure: action potential generation by isolated neuron under control and after TTX was added to perfusion solution.Compound should be sonicated when dissolved.
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Species: MouseAssay Type: In VitroWe use this to block cell activity of the brain slices, in order to keep the cells more healthy after they are dissociated. It works great and helps a lot for our purpose; but the only little problem is that it's very hard to dissolve in the water.
There are no reviews that match your criteria.