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Tetrodotoxin

Voltage-gated Sodium Channel Blockers Small Molecule

Key Product Details

Description: Na+ channel blocker
Alternative Names: TTx
Chemical Name: (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol
Purity: ≥98% (HPLC)
Molecular Weight: 319.27

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Citations for Tetrodotoxin (338)

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Customer Reviews (5)

4.8 out of 5
5 customer ratings
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  • Totally blocked action potential
    Name: Yuyang Sun
    Species: Mouse
    Assay Type: In Vitro
    Works great. Totally blocked the action potential in mouse brain slice.
    Tetrodotoxin Serum 1078
  • Validation
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    10 μM for 30min
    Tetrodotoxin Serum 1078
  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: Other
    Assay Type: In Vitro
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    Tetrodotoxin Serum 1078
  • TTX blocks action potential propagation
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Hippocampus
    Tetrodotoxin (TTX) was used to block action potential propagation in response to lasting current injection into living neuron. This illustrated a critical role of voltage-gated sodium channels in inter-neuronal crosstalk. 1 microM of TTX developed 100% effect (see Figure). Figure: action potential generation by isolated neuron under control and after TTX was added to perfusion solution.
    Compound should be sonicated when dissolved.
    Tetrodotoxin Serum 1078
  • good drug for neuronal activity inhibition
    Name: Lihua Wang
    Species: Mouse
    Assay Type: In Vitro
    We use this to block cell activity of the brain slices, in order to keep the cells more healthy after they are dissociated. It works great and helps a lot for our purpose; but the only little problem is that it's very hard to dissolve in the water.

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