Teriflunomide

Tocris Bioscience, part of Bio-Techne | Catalog # 5069

Inhibitor of DHODH; active metabolite of Leflunomide
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Key Product Details

Description

Inhibitor of DHODH; active metabolite of Leflunomide

Alternative Names

A77 1726

View all DHODH Inhibitors »

Product Description

Teriflunomide is an inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Immunosuppressive agent. Active metabolite of leflunomide.

Product Specifications

Molecular Weight

270.21

Formula

C12H9F3N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide

CAS Number

108605-62-5

PubChem ID

54684141

InChI Key

UTNUDOFZCWSZMS-YFHOEESVSA-N

SMILES

O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.02 100

Preparing Stock Solutions for Teriflunomide

The following data is based on the product molecular weight 270.21

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.70 mL 18.50 mL 37.01 mL
5 mM 0.74 mL 3.70 mL 7.40 mL
10 mM 0.37 mL 1.85 mL 3.70 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Reconstitution Calculator

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Product Documents for Teriflunomide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Teriflunomide

For research use only

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