Teriflunomide

Name: Teriflunomide
Brand: Tocris Bioscience
SKU: 5069

Tocris Bioscience, part of Bio-Techne | Catalog # 5069

Citations (17)

COA / SDS

Inhibitor of DHODH; active metabolite of Leflunomide

Key Product Details

Description:	Inhibitor of DHODH; active metabolite of Leflunomide
Alternative Names:	A77 1726
Chemical Name:	2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Purity:	≥98% (HPLC)
Molecular Weight:	270.21

View Full Technical Details for Teriflunomide

Technical Data
Citations

Biological Activity for Teriflunomide

Teriflunomide is an inhibitor of dihydroorotate dehydrogenase (K_d = 12 nM; K_i = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G₁ to S. Immunosuppressive agent. Active metabolite of leflunomide.

Compound Libraries for Teriflunomide

Teriflunomide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Teriflunomide

M. Wt	270.21
Formula	C₁₂H₉F₃N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	108605-62-5
PubChem ID	54684141
InChi Key	UTNUDOFZCWSZMS-YFHOEESVSA-N
Smiles	O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Teriflunomide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.02	100

Preparing Stock Solutions for Teriflunomide

The following data is based on the product molecular weight 270.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.70 mL	18.50 mL	37.01 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
10 mM	0.37 mL	1.85 mL	3.70 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for Teriflunomide

References are publications that support the biological activity of the product.

Davis The immunosuppressive metabolite of leflun. is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 1996 PMID: 8573583
Iglesias-Bregna Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 2013 PMID: 23892570
Williamson Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J.Biol.Chem. 1995 PMID: 7673235