Tenofovir is a selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC₅₀ = 1.5 μM). Antiviral agent.

Product Specifications

Molecular Weight

287.21

Formula

C₉H₁₄N₅O₄P

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid

CAS Number

147127-20-6

PubChem ID

464205

InChI Key

SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES

C[C@@H](OCP(O)(O)=O)CN(C=N2)C1=C2C(N)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1.1eq. NaOH	28.72	100
	DMSO	2.87	10

Preparing Stock Solutions for Tenofovir

The following data is based on the product molecular weight 287.21

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.41 mL	34.82 mL
5 mM	0.70 mL	3.48 mL	6.96 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Van Rompay 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 1996 PMID: 8913470
Suo Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 1998 PMID: 9765248
Tsai Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 1995 PMID: 7502044

Tenofovir

Tocris Bioscience, part of Bio-Techne | Catalog # 3666

Key Product Details

Description

Alternative Names

View all RNA/DNA Polymerase Inhibitors »

Product Description